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N Engl J Med. 2017 Jun 22;376(25):2437-2447. doi: 10.1056/NEJMoa1615715.

Cluster-Randomized, Crossover Trial of Head Positioning in Acute Stroke.

Collaborators (617)

Preto R, Heritier S, Lindley R, Jan S, Boaden E, Herbert R, Chen CPLH, Forster A, Scaria A, Espinosa N, McEvoy L, Blackburn L, Richtering SS, You S, Ladwig S, Merritt GP, Thomsen B, Jenson K, Gordon P, Nguyen DR, Quan WW, Lo TP, Lim J, Goh S, Ivanova E, Liu L, Baig MA, Singh R, Donnelly P, Armenis M, Van Zyl M, Monaghan H, Smith P, Glass P, Zhou F, Shen Y, Lei L, Li D, Zhang T, Zhang X, Peng Y, Feng L, Ye Z, Gregory P, Arora D, Gonzalez F, Portales B, Pontes-Neto O, Santos-Pontelli T, Rimoli B, Braga M, Hoffmeister L, Vidal C, Benadof D, Rivas RJ, Carvallo L, Carvallo P, Miranda R, Pileggi B, Weerawardena S, Jeevarajah T, Dharmawardena D, Ranasinghe D, Dharshana M, Shafras MMM, Nandadeva N, Nawarathna S, Yin JH, Yeh SJ, Ma RJ, Whiteley G, Cox J, Fitzgerald J, Heney JF, Byfield H, Finley S, Tyrer HE, Bruce C, Gibbon A, Jones B, Siracusa E, Gowda K, Cowans S, Forman B, Jacob S, Caprecho K, Khatri R, Wan PY, Lopez M, Vanika S, Bleeker W, Ireland M, Jala S, Day S, Ha E, Krause M, Passer M, Giaccari S, Burkolter N, Braithwaite M, Tastula K, Ghia D, Musuka T, Alvaro A, Edmonds G, O'Loughin N, Phair R, Kaoutal J, Blacker DJ, Saint BL, Parrey K, Coad M, Kinchington M, Senanayake N, Alaban J, Kuehne I, Camilo M, Libardi M, Martins S, Carlos B, Martins M, Carbonera L, Almeida A, Kelin M, Martins G, Pauli C, Lunardi M, Silveira L, Chagas O, Souza D, Bazan R, Braga G, Ribeiro P, Luvizutto G, Polin M, Winckler F, Liu J, Wang Z, Wang H, Lin S, Dong J, Zhou J, Qin S, Zhan H, Xue Y, Tian D, Yang D, Yin Y, Li H, Geng C, Liu J, Jiang X, Wu Y, Sun W, Yu B, Guan Y, Wang Q, Wei B, Wang H, Wang Y, Tai L, Zhang W, Zhao W, Wang X, Li G, Ni Z, Guo F, Cen L, Lu J, Chen Z, Yin G, Wang Y, Zheng J, Zhou Z, Wang H, Zou R, Xue B, Li A, Guo J, Guo Y, Jiang X, Tan X, Zhang C, Shao B, Niu X, Liu C, Chen D, Liang P, Zhang X, Zhang C, Gong W, Huang Z, Liu H, Huang J, Shi R, Wang C, Liu Y, Wang J, Wu G, Gao Z, Lin Q, Xu C, Zheng H, Ye X, Jin X, Liu J, Cao X, Zhang Y, Wang J, Xu Y, Li Y, Ma X, Kong Q, Hao Y, Qiao B, Yan H, Huang Z, Chang B, Yan J, Liao P, Zhang W, Liu L, Zhu T, Liu X, Li Y, Dong R, Chen M, Ge X, Wang H, Dai L, Liu J, Wang S, Du J, Song A, Li Y, Feng J, Yu C, Feng H, Sun X, Sun R, Liu W, Liu J, Lu X, Chen E, Gao W, Liu H, Wang H, Wang Y, Song J, Liu D, Du W, Li G, Li C, Liang Y, Cai X, Zhang J, Tao X, An P, Tang R, Qin X, Wang Y, Zhang W, Ma R, Huang X, Liu Y, Wang Y, Fan P, Yang H, Feng L, Zhi J, Zhang J, Zhou Y, Wu D, He H, Chen X, Hou Y, Su X, Fan S, Suárez L, de Dios Polanco J, Sotomayor P, Urzúa R, Urrutia D, Conejan N, Escobar A, Gonzalez M, Vargas D, Constante A, Vásquez E, Godoy E, Figueroa C, San Martin V, Vidal N, Muñoz M, Spencer M, Almeida J, Acosta I, Guerrero R, Lozano P, Aguayo C, Pizarro J, Soto A, Bonilla F, García P, Del Castillo C, Grandjean M, Von Johnn A, Gutierrez I, Rivero F, López I, Silva F, Pachón M, Mendoza J, Pabón A, Kate M, Akhtar N, Narang GS, Deepak A, Huded V, De Sowza R, Sigamani A, Rajendran K, Vishwanath A, K A, Kumaravelu S, Rahamath S, Kannneganti S, Khurana D, Katoch C, Kaur T, Karadan U, Kuriakose A, John J, Basheer M, Sylaja PN, Sreedharan SE, Gunasekara HH, De Silva GCU, Ubeywickrama PHL, Silva KC, De Silva EA, Ranawaka U, Mettananda C, Nanayakkara Y, Mendis T, Fernando G, Imthikab A, Pieris K, Gunatilake SB, Madanayake PMW, Paranavitane SA, Senanayake B, Vishwanathan V, Sivapalan M, Murage RU, Chandradeva U, Liu YH, Lin CL, Lin HF, Liu KT, Chen CF, Wu MN, Tsai SH, Chen CC, Chen LY, Chang CH, Chang YJ, Huang KL, Chang TY, Liu CH, Seak CJ, Lin YL, Luo JY, Yang HY, Wang CY, Chan L, Hu CJ, Chi NF, Wu D, Huang YH, Kuan YC, Hong CT, Chen YC, Sun Y, Lin CH, Lu CJ, Chu HJ, Lo YC, Chang WH, Lin WJ, Su HC, Lin TY, Cho CH, Lu SL, Hsueh YF, Lai CY, Jarrett D, James C, Valentine S, Whistler C, Butler R, Browning S, Watchurst C, Erande R, Elliott E, Patel K, Brezitski M, Hogan C, Banaras A, Crook L, Ahmed R, Potter L, Laird R, Patel B, Clarke N, Loosemore A, Godber J, Gawned S, Hamilton KA, Jones R, Guyler P, Tysoe S, Prabakaran R, Shah S, Calver J, Sztriha LK, Fitzpatrick M, Drysdale S, Aeron-Thomas J, McKenzie E, Chitando B, Willcoxson P, Iveson E, Wanklyn P, Dyer N, Keeling M, Rodriguez R, Elliott K, Porteous M, O'Neill M, Orme S, Richardson C, Tomlinson J, Hawkins S, Bester D, Jeffs C, Howard J, Brown P, Ward D, Turfrey J, Raybould L, Bates A, O'Connell S, O'Connor M, Williams S, Emsley HCA, McLoughlin A, Raj S, Gregary B, Doyle D, Courtauld GM, Schofield C, Lucas L, Lydon A, James A, Saastamoinen K, Howaniec L, Daboo P, Ali AN, Richards E, Howe J, Kamara C, Stocks K, Lindert R, Day DJ, Finlay S, McGee J, Mitchell J, Amis E, Macey R, Tauro S, Henry L, Cuddy S, Steele A, Mullen K, Kirker S, Bhattad M, Carpenter M, Datta P, Needle A, Jackson L, Ball J, Beckitt R, Devon R, Chivers N, Bowring A, Eddy S, Thorpe K, Keenan S, Griffin A, Maguire S, Patterson C, Ramadan H, Bellfield R, Hooley M, Stewart K, Williams L, Gurney C, Oliver D, Gardiner M, Grayland S, Bhandari M, Collas DM, Adesina T, Sundayi S, Harvey R, Pope E, Lam A, Walker E, Merrill C, Banerjee S, Harvey KH, Mashate S, Wilding P, Johnson L, Namushi R, Jacob P, Andole S, Dunne K, Gadapa N, King S, Patel R, Siliuzaite S, Dealing S, Attwood K, Sanmuganathan S, Woods A, Sandhu B, Mamun M, Mahmood A, Jones J, Ojo A, Carter-Evans D, Fitzsimmons P, Manoj A, Fletcher G, Lopez P, Rana PS, Greig J, Robinson M, Jones P, Jones S, Jones L, West C, Tench H, Potter S, Gascoyne R, Whileman A, Hall E, Wright S, Toms J, Sekaran L, Phiri D, Sethuraman S, Mohammed N, Justin F, Tate ML, Chauhan M, Chatterjee K, Haider SI, Nallasivan A, Webster T, Leason S, Seagrave S, Subramonian S, Owksu-Agyei P, Temple N, Butterworth-Cowin N, Magezi F, Turner E, Khan S, Stephens C, Mistri A, Murphy A, Lam M, Underwood P, Thompson C, Smith C, Buckley C, Wood D, Board S, Howard L, Johnson S, Ahmed A, Oates B, Jenkinson DF, Leonard S, Jupp BJ, Thavanesan K, Dharmasiri M, Logianathan S, Ovington C, Hann G, Cox C, McCormick MT, Douglas C, Goggin M, Fearon P, Gilpin S, O'Hagan M, Mangion DM, Hardwick A, Netherton K, Ni H, Quinn J, Bozkaplan T, Jose J.

Abstract

BACKGROUND:

The role of supine positioning after acute stroke in improving cerebral blood flow and the countervailing risk of aspiration pneumonia have led to variation in head positioning in clinical practice. We wanted to determine whether outcomes in patients with acute ischemic stroke could be improved by positioning the patient to be lying flat (i.e., fully supine with the back horizontal and the face upwards) during treatment to increase cerebral perfusion.

METHODS:

In a pragmatic, cluster-randomized, crossover trial conducted in nine countries, we assigned 11,093 patients with acute stroke (85% of the strokes were ischemic) to receive care in either a lying-flat position or a sitting-up position with the head elevated to at least 30 degrees, according to the randomization assignment of the hospital to which they were admitted; the designated position was initiated soon after hospital admission and was maintained for 24 hours. The primary outcome was degree of disability at 90 days, as assessed with the use of the modified Rankin scale (scores range from 0 to 6, with higher scores indicating greater disability and a score of 6 indicating death).

RESULTS:

The median interval between the onset of stroke symptoms and the initiation of the assigned position was 14 hours (interquartile range, 5 to 35). Patients in the lying-flat group were less likely than patients in the sitting-up group to maintain the position for 24 hours (87% vs. 95%, P<0.001). In a proportional-odds model, there was no significant shift in the distribution of 90-day disability outcomes on the global modified Rankin scale between patients in the lying-flat group and patients in the sitting-up group (unadjusted odds ratio for a difference in the distribution of scores on the modified Rankin scale in the lying-flat group, 1.01; 95% confidence interval, 0.92 to 1.10; P=0.84). Mortality within 90 days was 7.3% among the patients in the lying-flat group and 7.4% among the patients in the sitting-up group (P=0.83). There were no significant between-group differences in the rates of serious adverse events, including pneumonia.

CONCLUSIONS:

Disability outcomes after acute stroke did not differ significantly between patients assigned to a lying-flat position for 24 hours and patients assigned to a sitting-up position with the head elevated to at least 30 degrees for 24 hours. (Funded by the National Health and Medical Research Council of Australia; HeadPoST ClinicalTrials.gov number, NCT02162017 .).

Comment in

PMID:
28636854
DOI:
10.1056/NEJMoa1615715
[Indexed for MEDLINE]
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