Format

Send to

Choose Destination
Nature. 2017 Jun 29;546(7660):656-661. doi: 10.1038/nature22815. Epub 2017 Jun 21.

T cells from patients with Parkinson's disease recognize α-synuclein peptides.

Author information

1
Departments of Psychiatry, Columbia University, Division of Molcular Therapeutics, New York State Psychiatric Institute, New York, New York 10032, USA.
2
Department of Neurology, Columbia University, New York, New York 10032, USA.
3
Department of Pharmacology, Columbia University, New York, New York 10032, USA.
4
Department of Microbiology and Immunology, University of Oklahoma, Oklahoma City, Oklahoma 73104, USA.
5
Neuroregeneration and Stem Cell Program, Institute for Cell Engineering and the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
6
Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130-2685, USA.
7
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
8
Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
9
Department of Pharmacology &Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
10
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA.
11
Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia 6150, Australia.

Abstract

Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson's disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease. These responses may explain the association of Parkinson's disease with specific major histocompatibility complex alleles.

Comment in

PMID:
28636593
PMCID:
PMC5626019
DOI:
10.1038/nature22815
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center