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Acta Ophthalmol. 2018 Aug;96(5):e577-e581. doi: 10.1111/aos.13509. Epub 2017 Jun 21.

Selective laser trabeculoplasty as replacement therapy in medically controlled glaucoma patients.

Author information

1
Department of Medicine, University of Antwerp, Antwerp, Belgium.
2
Department of Experimental Psychology, Ghent University, Ghent, Belgium.
3
Department of Ophthalmology, University Hospital Antwerp, Edegem, Belgium.

Abstract

PURPOSE:

We examined selective laser trabeculoplasty (SLT) as a replacement therapy for medically controlled open-angle glaucoma (OAG) or ocular hypertensive patients.

METHODS:

A prospective randomized interventional clinical trial on 143 glaucoma patients. Patients were randomized to either receiving SLT or to the control group that continued on pressure lowering medication. Data were recorded 1 hr, 1 week, 1, 3, 6, 12 and 18 months after SLT. Primary outcome was number of medications at 12 and 18 months while maintaining a predetermined target intraocular pressure (IOP).

RESULTS:

Selective laser trabeculoplasty (SLT) reduced number of medications from a mean of 1.5 at baseline, to 0.35 after 12 months and 0.29 after 18 months. Meanwhile, SLT achieved more than 20% IOP lowering in 95% of eyes and more than 30% IOP lowering in 86% of eyes after 18 months. Seventy-seven per cent of our eyes no longer needed any medication after SLT at 18 months.

CONCLUSION:

Selective laser trabeculoplasty (SLT) enabled a reduction in number of medications while maintaining good IOP control. Selective laser trabeculoplasty (SLT) was able to completely replace medical therapy in 77% of eyes after 18 months. Selective laser trabeculoplasty (SLT) as replacement therapy may reduce local and systemic side-effects and prevent adherence issues.

KEYWORDS:

glaucoma; ocular hypertension; replacement therapy; selective laser trabeculoplasty

PMID:
28636188
DOI:
10.1111/aos.13509
[Indexed for MEDLINE]

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