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Vox Sang. 2017 Aug;112(6):595-597. doi: 10.1111/vox.12539. Epub 2017 Jun 21.

Prothrombin complex concentrate for emergent reversal of warfarin: an international survey of hospital protocols.

Author information

1
Innovative Blood Resources/Memorial Blood Centers, St. Paul, MN, USA.
2
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
3
Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT, USA.
4
Ottawa Hospital Centre for Transfusion Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Abstract

For emergent warfarin reversal, four-factor prothrombin complex concentrates (4FPCCs) are recommended by many international guidelines. We surveyed international clinical sites including members of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative. Most sites have emergent warfarin reversal protocols (53% use PCC, 25% use PCC+ plasma and 2% use plasma alone); however, variation between adjusted dosing and fixed dosing was observed.

KEYWORDS:

dosing strategy; prothrombin complex concentrate; protocol; warfarin reversal

PMID:
28635130
DOI:
10.1111/vox.12539
[Indexed for MEDLINE]

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