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Arthritis Care Res (Hoboken). 2018 Mar;70(3):327-332. doi: 10.1002/acr.23295. Epub 2018 Feb 6.

Relationship Between Fish Consumption and Disease Activity in Rheumatoid Arthritis.

Author information

1
Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
2
Columbia University College of Physicians & Surgeons and New York-Presbyterian Hospital, New York.
3
Brigham and Women's Hospital and Harvard Medical School, and Harvard T. H. Chan School of Public Health, Boston, Massachusetts.

Abstract

OBJECTIVE:

To assess whether more frequent fish consumption is associated with lower rheumatoid arthritis (RA) disease activity scores among participants in an RA cohort.

METHODS:

We conducted a cross-sectional analysis using baseline data from participants in the Evaluation of Subclinical Cardiovascular Disease and Predictors of Events in Rheumatoid Arthritis cohort study. Frequency of fish consumption was assessed by a baseline food frequency questionnaire assessing usual diet in the past year. Multivariable, total energy-adjusted linear regression models provided effect estimates and 95% confidence intervals (95% CIs) for frequency of fish consumption (i.e., never to <1 time/month, 1 time/month to <1 time/week, 1 time/week, and ≥2 times/week) on baseline Disease Activity Score in 28 joints (DAS28) using the C-reactive protein (CRP) level. We also estimated the difference in DAS28-CRP associated with increasing fish consumption by 1 serving per week.

RESULTS:

Among 176 participants, the median DAS28-CRP score was 3.5 (interquartile range 2.9-4.3). In an adjusted linear regression model, subjects consuming fish ≥2 times/week had a significantly lower DAS28-CRP compared with subjects who ate fish never to <1 time/month (difference -0.49 [95% CI -0.97, -0.02]). For each additional serving of fish per week, DAS28-CRP was significantly reduced by 0.18 (95% CI -0.35, -0.004).

CONCLUSION:

Our findings suggest that higher intake of fish may be associated with lower disease activity in RA patients.

PMID:
28635117
PMCID:
PMC5740014
DOI:
10.1002/acr.23295
[Indexed for MEDLINE]
Free PMC Article

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