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Virus Genes. 2017 Oct;53(5):741-748. doi: 10.1007/s11262-017-1482-7. Epub 2017 Jun 20.

Herpesviral vectors and their application in oncolytic therapy, vaccination, and gene transfer.

Author information

1
Institute for Interfacial Engineering and Plasma Technology IGVP, University of Stuttgart, Nobelstrasse 12, 70569, Stuttgart, Germany. Susanne.Bailer@igvp.uni-stuttgart.de.
2
Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB, Nobelstrasse 12, 70569, Stuttgart, Germany. Susanne.Bailer@igvp.uni-stuttgart.de.
3
Institute for Interfacial Engineering and Plasma Technology IGVP, University of Stuttgart, Nobelstrasse 12, 70569, Stuttgart, Germany.
4
Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB, Nobelstrasse 12, 70569, Stuttgart, Germany.
5
Department for Medical Microbiology and Hygiene, Institute of Virology, University Medical Center Freiburg, Hermann-Herder-Strasse 11, 79104, Freiburg, Germany.
6
German Center for Infection Research - DZIF, Freiburg, Germany.
7
Department for Medical Microbiology and Hygiene, Institute of Virology, University Medical Center Freiburg, Hermann-Herder-Strasse 11, 79104, Freiburg, Germany. zsolt.ruzsics@uniklinik-freiburg.de.
8
German Center for Infection Research - DZIF, Freiburg, Germany. zsolt.ruzsics@uniklinik-freiburg.de.

Abstract

Herpesviruses are enveloped DNA viruses that infect vertebrate cells. Their high potential cloning capacity and the lifelong persistence of their genomes in various host cells make them attractive platforms for vector-based therapy. In this review, we would like to highlight recent advances of three major areas of herpesvirus vector development and application: (i) oncolytic therapy, (ii) recombinant vaccines, and (iii) large capacity gene transfer vehicles.

KEYWORDS:

BAC technology; Gene transfer; Herpesviral vectors; High-capacity cloning; Oncolytic therapy; Vaccination

PMID:
28634751
DOI:
10.1007/s11262-017-1482-7
[Indexed for MEDLINE]

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