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Emerg Microbes Infect. 2017 Jun 21;6(6):e56. doi: 10.1038/emi.2017.44.

Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014-2015.

Author information

1
Department of Microbiology and Parasitology, College of Veterinary Medicine, King Faisal University, Alhufuf, Al-Ahsa 31982, Saudi Arabia.
2
Department of Virology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.
3
Department of Clinical Studies, College of Veterinary Medicine, King Faisal University, Alhufuf, Al-Ahsa 31982, Saudi Arabia.
4
School of Public Health, The University of Hong Kong, Hong Kong, China.
5
Department of Public Health and Animal Welfare, College of Veterinary Medicine, King Faisal University, Alhufuf, Al-Ahsa 31982, Saudi Arabia.
6
Division of Virology, Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN 38105, USA.

Abstract

Two herds of dromedary camels were longitudinally sampled with nasal and rectal swabs and serum, between September 2014 and May 2015, and the samples were tested for Middle East Respiratory Syndrome (MERS) coronavirus RNA and antibodies. Evidence of MERS-CoV infection was confirmed in one herd on the basis of detection of virus RNA in nasal swabs from three camels and significant increases in the antibody titers from three others. The three viruses were genetically identical, thus indicating introduction of a single virus into this herd. There was evidence of reinfection of camels that were previously seropositive, thus suggesting that prior infection does not provide complete immunity from reinfection, a finding that is relevant to camel vaccination strategies as a means to prevent zoonotic transmission.

PMID:
28634355
PMCID:
PMC5520318
DOI:
10.1038/emi.2017.44
[Indexed for MEDLINE]
Free PMC Article

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