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Mol Neurodegener. 2017 Jun 21;12(1):49. doi: 10.1186/s13024-017-0190-z.

Targeting psychologic stress signaling pathways in Alzheimer's disease.

Futch HS1,2,3, Croft CL1,2,3, Truong VQ1,2,3, Krause EG4,3, Golde TE5,6,7.

Author information

1
Department of Neuroscience, University of Florida, Gainesville, FL, 32610, USA.
2
Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, 32610, USA.
3
McKnight Brain Institute, University of Florida, 1149 Newell Drive, PO Box 1000015, Gainesville, FL, 32610, USA.
4
Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, USA.
5
Department of Neuroscience, University of Florida, Gainesville, FL, 32610, USA. tgolde@ufl.edu.
6
Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, 32610, USA. tgolde@ufl.edu.
7
McKnight Brain Institute, University of Florida, 1149 Newell Drive, PO Box 1000015, Gainesville, FL, 32610, USA. tgolde@ufl.edu.

Abstract

Alzheimer's Disease (AD) is the most prevalent progressive neurodegenerative disease; to date, no AD therapy has proven effective in delaying or preventing the disease course. In the search for novel therapeutic targets in AD, it has been shown that increased chronic psychologic stress is associated with AD risk. Subsequently, biologic pathways underlying psychologic stress have been identified and shown to be able to exacerbate AD relevant pathologies. In this review, we summarize the literature relevant to the association between psychologic stress and AD, focusing on studies investigating the effects of stress paradigms on transgenic mouse models of Amyloid-β (Aβ) and tau pathologies. In recent years, a substantial amount of research has been done investigating a key stress-response mediator, corticotropin-releasing hormone (CRH), and its interactions with AD relevant processes. We highlight attempts to target the CRH signaling pathway as a therapeutic intervention in these transgenic mouse models and discuss how targeting this pathway is a promising avenue for further investigation.

KEYWORDS:

Alzheimer’s disease; Chronic stress; Corticotropin-releasing hormone; Neurodegeneration; Psychologic distress

PMID:
28633663
PMCID:
PMC5479037
DOI:
10.1186/s13024-017-0190-z
[Indexed for MEDLINE]
Free PMC Article

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