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Dev Cell. 2017 Jun 19;41(6):574-576. doi: 10.1016/j.devcel.2017.06.008.

Morph or Move? How Distinct Endothelial Cell Responses to Blood Flow Shape Vascular Networks.

Author information

1
Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.
2
Max-Delbrück Center for Molecular Medicine, 13125 Berlin, Germany; Vascular Patterning Laboratory, Center for Cancer Biology, VIB, Department of Oncology, KU Leuven, 3000 Leuven, Belgium; DZHK (German Centre for Cardiovascular Research), partner site Berlin, 13347 Berlin, Germany; Berlin Institute of Health, 10117 Berlin, Germany. Electronic address: holger.gerhardt@mdc-berlin.de.

Abstract

Blood vessel shape is malleable and dynamically regulated. In two recent papers in Nature Cell Biology, Jin et al. (2017) and Sugden et al. (2017) show that endoglin alters endothelial cell shape or behavior in response to blood flow, thus regulating vessel structure.

PMID:
28633012
DOI:
10.1016/j.devcel.2017.06.008
[Indexed for MEDLINE]
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