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Nat Immunol. 2017 Jun 20;18(7):725-732. doi: 10.1038/ni.3768.

Systems immunology: just getting started.

Author information

1
Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, USA.
2
Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, California, USA.
3
Institute for Immunogenetics, Jose de San Martin Clinical Hospital, National Scientific and Technical Research Council, Buenos Aires, Argentina.

Abstract

Systems-biology approaches in immunology take various forms, but here we review strategies for measuring a broad swath of immunological functions as a means of discovering previously unknown relationships and phenomena and as a powerful way of understanding the immune system as a whole. This approach has rejuvenated the field of vaccine development and has fostered hope that new ways will be found to combat infectious diseases that have proven refractory to classical approaches. Systems immunology also presents an important new strategy for understanding human immunity directly, taking advantage of the many ways the immune system of humans can be manipulated.

PMID:
28632713
PMCID:
PMC5790187
DOI:
10.1038/ni.3768
[Indexed for MEDLINE]
Free PMC Article

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