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Diabet Med. 2017 Sep;34(9):1259-1263. doi: 10.1111/dme.13410. Epub 2017 Jul 12.

Serious life events and the risk of latent autoimmune diabetes in adults (LADA) and Type 2 diabetes.

Author information

1
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
2
Center for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden.
3
Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
4
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
5
Department of Clinical Sciences in Malmö, Clinical Research Centre, Lund University, Malmö, Sweden.
6
Finnish Institute of Molecular Medicine, Helsinki University, Helsinki, Finland.
7
Division of Endocrinology, Abdominal Center, Helsinki University Hospital, Research Program for Diabetes and Obesity, University of Helsinki, Helsinki, Finland.
8
Folkhälsan Research Center, Helsinki, Finland.

Abstract

AIM:

It has been suggested that experiencing serious life events may promote Type 1 diabetes in children. Studies in adults are lacking, as are studies on the interaction of life events with genetic factors. We aimed to investigate life events and the risk of latent autoimmune diabetes in adults (LADA) and Type 2 diabetes while taking into account HLA genotype.

METHODS:

Analysis was based on 425 incident cases of LADA, 1417 incident cases of Type 2 diabetes and 1702 population-based controls recruited in Sweden between 2010 and 2016. Self-reported information on life events including conflicts, divorce, illness/accidents, death and financial problems experienced during the 5 years preceding diagnosis/index year was used. Odds ratios (ORs) and 95% confidence intervals (95% CI) were calculated by logistic regression and adjusted for age, sex, BMI, family history of diabetes, smoking, physical activity and education.

RESULTS:

Overall there was no association between experience of any life event and either LADA (OR 0.86, 95% CI 0.68-1.08) or Type 2 diabetes (OR 1.00, 95% CI 0.83-1.21). The results were similar for individual events as well as in separate analysis of men and women. Similar results were seen in more autoimmune LADA (glutamic acid decarboxylase antibodies > median) [OR (any life event) 0.88, 95% CI 0.64-1.21] and in LADA carriers of the high-risk HLADR4-DQ8 genotype (OR 0.89, 95% CI 0.61-1.29).

CONCLUSIONS:

Our findings indicate that experience of a serious life event, including the death of a family member, divorce or financial problems, is not associated with an increased risk of LADA, overall or in genetically susceptible individuals.

PMID:
28632336
DOI:
10.1111/dme.13410
[Indexed for MEDLINE]

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