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Int J Mol Sci. 2017 Jun 20;18(6). pii: E1310. doi: 10.3390/ijms18061310.

Microbiota, Inflammation and Colorectal Cancer.

Author information

1
M2iSH, UMR 1071 Inserm, University of Clermont Auvergne, INRA USC 2018, Clermont-Ferrand 63001, France. cecily.lucas@uca.fr.
2
M2iSH, UMR 1071 Inserm, University of Clermont Auvergne, INRA USC 2018, Clermont-Ferrand 63001, France. nicolas.barnich@uca.fr.
3
M2iSH, UMR 1071 Inserm, University of Clermont Auvergne, INRA USC 2018, Clermont-Ferrand 63001, France. hang.nguyen@uca.fr.

Abstract

Colorectal cancer, the fourth leading cause of cancer-related death worldwide, is a multifactorial disease involving genetic, environmental and lifestyle risk factors. In addition, increased evidence has established a role for the intestinal microbiota in the development of colorectal cancer. Indeed, changes in the intestinal microbiota composition in colorectal cancer patients compared to control subjects have been reported. Several bacterial species have been shown to exhibit the pro-inflammatory and pro-carcinogenic properties, which could consequently have an impact on colorectal carcinogenesis. This review will summarize the current knowledge about the potential links between the intestinal microbiota and colorectal cancer, with a focus on the pro-carcinogenic properties of bacterial microbiota such as induction of inflammation, the biosynthesis of genotoxins that interfere with cell cycle regulation and the production of toxic metabolites. Finally, we will describe the potential therapeutic strategies based on intestinal microbiota manipulation for colorectal cancer treatment.

KEYWORDS:

colorectal cancer; genotoxins; host-pathogen interaction; inflammation; intestinal microbiota

PMID:
28632155
PMCID:
PMC5486131
DOI:
10.3390/ijms18061310
[Indexed for MEDLINE]
Free PMC Article

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