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Curr Neurol Neurosci Rep. 2017 Aug;17(8):56. doi: 10.1007/s11910-017-0766-6.

The Use of Cannabinoids in Treating Dementia.

Weier M1,2, Hall W3,4.

Author information

1
National Drug and Alcohol Research Centre, The University of New South Wales, Sydney, Australia.
2
The Centre for Youth Substance Abuse Research, The University of Queensland, Brisbane, Australia.
3
The Centre for Youth Substance Abuse Research, The University of Queensland, Brisbane, Australia. w.hall@uq.edu.au.
4
National Addiction Centre, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK. w.hall@uq.edu.au.

Abstract

PURPOSE OF REVIEW:

To review and summarise the current evidence on the safety and efficacy of using cannabinoids to treat behavioural and neuropsychiatric symptoms of dementia.

RECENT FINDINGS:

Two randomised controlled trials testing a synthetic form of tetrahydrocannabinol have shown that while well tolerated, there was no significant therapeutic effect, based on changes to scores on the neuropsychiatric inventory (NPI). Case reports and open label trials have indicated that there may be some therapeutic benefit of adding synthetic cannabinoids as an adjunctive therapy to reduce agitation, aberrant motor behaviour and nighttime behaviour. More well-controlled clinical trials in older populations with varying severity of dementia are needed to evaluate the effectiveness of cannabinoids in treating behaviour symptoms of dementia. We provide suggestions for designing such trials and evaluating possible adverse effects of cannabinoids on cognitive and neuropsychiatric functioning.

KEYWORDS:

Alzheimer’s disease; Cannabinoids; Dementia; Neuropsychiatric inventory; Pharmacotherapies

PMID:
28631194
DOI:
10.1007/s11910-017-0766-6
[Indexed for MEDLINE]

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