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J Gastrointest Cancer. 2017 Jun 20. doi: 10.1007/s12029-017-9971-4. [Epub ahead of print]

Validation of a Liver Index and Its Significance for HCC Aggressiveness.

Author information

1
Izmir Biomedicine and Genome Center, Dokuz Eylul University, Izmir, Turkey. brianicarr@hotmail.com.
2
Department of Clinical Trials, IRCCS de Bellis, Castellana Grotte, Italy.

Abstract

BACKGROUND:

We recently constructed a liver index (LI) from four liver parameters, namely: blood total bilirubin, gamma glutamyl transpeptidase (GGTP), albumin, and platelet levels (a cirrhosis surrogate). We found that the scores for the liver index related significantly to a four-parameter HCC aggressiveness index (maximum tumor diameter, multifocality, percent portal vein invasion, and blood AFP levels).

AIMS:

To validate the relationship of liver parameters to tumor aggressiveness parameters in a larger, different HCC dataset.

RESULTS:

We now confirm these associations in another large HCC cohort. Furthermore, this liver index showed significant trends with the individual HCC aggressiveness parameters.

CONCLUSIONS:

These results provide further support for the idea that liver microenvironment, as reflected in liver function tests, may relate to HCC behavior.

KEYWORDS:

Aggressiveness index; HCC parameters; Liver function

PMID:
28631027
DOI:
10.1007/s12029-017-9971-4

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