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Philos Trans R Soc Lond B Biol Sci. 2017 Aug 5;372(1726). pii: 20160217. doi: 10.1098/rstb.2016.0217.

Apoptotic foci at mitochondria: in and around Bax pores.

Author information

1
Interfaculty Institute of Biochemistry, University of Tübingen, Hoppe Seyler Straße 4, 72076 Tübingen, Germany.
2
Biofisika Institute (UPV/EHU, CSIC), Department of Biochemistry and Molecular Biology, University of the Basque Country (UPV/EHU), Barrio Sarriena s/n, 48940 Leioa, Spain.
3
Interfaculty Institute of Biochemistry, University of Tübingen, Hoppe Seyler Straße 4, 72076 Tübingen, Germany ana.garcia@uni-tuebingen.de.
4
Max Planck Institute for Intelligent Systems, Stuttgart, Germany.

Abstract

The permeabilization of the mitochondrial outer membrane by Bax and Bak during apoptosis is considered a key step and a point of no return in the signalling pathway. It is always closely related to the reorganization of mitochondrial cristae that frees cytochrome c to the intermembrane space and to massive mitochondrial fragmentation mediated by the dynamin-like protein Drp1. Despite multiple evidence in favour of a functional link between these processes, the molecular mechanisms that connect them and their relevance for efficient apoptosis signalling remain obscure. In this review, we discuss recent progress on our understanding of how Bax forms pores in the context of Drp1-stabilized signalling platforms at apoptotic foci in mitochondria.This article is part of the themed issue 'Membrane pores: from structure and assembly, to medicine and technology'.

KEYWORDS:

Bcl-2; MOMP; cristae remodelling; membrane curvature; mitochondrial fragmentation

PMID:
28630156
PMCID:
PMC5483519
DOI:
10.1098/rstb.2016.0217
[Indexed for MEDLINE]
Free PMC Article

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