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EBioMedicine. 2017 Jul;21:79-85. doi: 10.1016/j.ebiom.2017.06.005. Epub 2017 Jun 6.

Use of Underarm Cosmetic Products in Relation to Risk of Breast Cancer: A Case-Control Study.

Author information

1
Department of Medical Statistics, Informatics and Health Economics, Medical University of Innsbruck, Austria.
2
Division of Clinical Biochemistry, Biocenter, Medical University of Innsbruck, Austria.
3
Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, Austria.
4
The Birchall Centre, Lennard-Jones Laboratories, Keele University, UK.
5
Department of Obstetrics and Gynecology, Medical University of Innsbruck, Austria.
6
Department of Obstetrics and Gynecology, Medical University of Innsbruck, Austria. Electronic address: nicole.concin@i-med.ac.at.
7
Department of Medical Statistics, Informatics and Health Economics, Medical University of Innsbruck, Austria. Electronic address: hanno.ulmer@i-med.ac.at.

Abstract

BACKGROUND:

Previous studies on breast cancer (BC), underarm cosmetic products (UCP) and aluminum salts have shown conflicting results. We conducted a 1:1 age-matched case-control study to investigate the risk for BC in relation to self-reported UCP application.

METHODS:

Self-reported history of UCP use was compared between 209 female BC patients (cases) and 209 healthy controls. Aluminum concentration in breast tissue was measured in 100 cases and 52 controls. Multivariable conditional logistic regression analysis was performed to estimate odds ratios (ORs) with 95% confidence intervals (CIs), adjusting for established BC risk factors.

FINDINGS:

Use of UCP was significantly associated with risk of BC (p=0.036). The risk for BC increased by an OR of 3.88 (95% CI 1.03-14.66) in women who reported using UCP's several times daily starting at an age earlier than 30years. Aluminum in breast tissue was found in both cases and controls and was significantly associated to self-reported UCP use (p=0.009). Median (interquartile) aluminum concentrations were significantly higher (p=0.001) in cases than in controls (5.8, 2.3-12.9 versus 3.8, 2.5-5.8nmol/g).

INTERPRETATION:

Frequent use of UCPs may lead to an accumulation of aluminum in breast tissue. More than daily use of UCPs at younger ages may increase the risk of BC.

KEYWORDS:

Aluminum; Breast cancer; Case-control study; Epidemiology; Underarm cosmetic products

PMID:
28629908
PMCID:
PMC5514401
DOI:
10.1016/j.ebiom.2017.06.005
[Indexed for MEDLINE]
Free PMC Article

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