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Chin J Cancer. 2017 Jun 19;36(1):50. doi: 10.1186/s40880-017-0217-4.

Cancer chemoprevention through dietary flavonoids: what's limiting?

Author information

1
Department of Pharmacology and Systems Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, 43560, USA.
2
Pharmaceutical Sciences, College of Pharmacy, St. John's University, Queens, NY, 11432, USA.
3
Department of Pharmacology and Systems Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, 43560, USA. amit.tiwari@utoledo.edu.
4
Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, 43614, USA. amit.tiwari@utoledo.edu.

Abstract

Flavonoids are polyphenols that are found in numerous edible plant species. Data obtained from preclinical and clinical studies suggest that specific flavonoids are chemo-preventive and cytotoxic against various cancers via a multitude of mechanisms. However, the clinical use of flavonoids is limited due to challenges associated with their effective use, including (1) the isolation and purification of flavonoids from their natural resources; (2) demonstration of the effects of flavonoids in reducing the risk of certain cancer, in tandem with the cost and time needed for epidemiological studies, and (3) numerous pharmacokinetic challenges (e.g., bioavailability, drug-drug interactions, and metabolic instability). Currently, numerous approaches are being used to surmount some of these challenges, thereby increasing the likelihood of flavonoids being used as chemo-preventive drugs in the clinic. In this review, we summarize the most important challenges and efforts that are being made to surmount these challenges.

KEYWORDS:

Chemoprevention; Flavonoids; Natural product drug development; Pharmacokinetic challenges; Silybin; Silymarin

PMID:
28629389
PMCID:
PMC5477375
DOI:
10.1186/s40880-017-0217-4
[Indexed for MEDLINE]
Free PMC Article

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