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Ann Neurol. 2017 Jul;82(1):147-151. doi: 10.1002/ana.24983.

Structural plasticity of the ventral stream and aphasia recovery.

Author information

1
Department of Neurology, Medical University of South Carolina, Charleston, SC.
2
Center for Biomedical Imaging, Medical University of South Carolina, Charleston, SC.
3
Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC.
4
Department of Communication Sciences and Disorders, University of South Carolina, Columbia, SC.
5
Department of Neuroscience, Medical University of South Carolina, Charleston, SC.
6
Department of Psychology, University of South Carolina, Columbia, SC.

Abstract

Restrengthening of the residual language network is likely to be crucial for speech recovery in poststroke aphasia. Eight participants with chronic aphasia received intensive speech therapy for 3 weeks, with standardized naming tests and brain magnetic resonance imaging before and after therapy. Kurtosis-based diffusion tensor tractography was used to measure mean kurtosis (MK) along a segment of the inferior longitudinal fasciculus (ILF). Therapy-related reduction in the number of semantic but not phonemic errors was associated with strengthening (renormalization) of ILF MK (r = -0.90, p < 0.05 corrected), suggesting that speech recovery is related to structural plasticity of language-specific components of the residual language network. Ann Neurol 2017;82:147-151.

PMID:
28628946
PMCID:
PMC5559663
DOI:
10.1002/ana.24983
[Indexed for MEDLINE]
Free PMC Article

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