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Eur J Med Chem. 2017 Sep 8;137:504-544. doi: 10.1016/j.ejmech.2017.06.005. Epub 2017 Jun 3.

Drug development against tuberculosis: Impact of alkaloids.

Author information

1
Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India; Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India.
2
Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India.
3
Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, India.
4
Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India. Electronic address: Tiwari_chem@yahoo.co.in.

Abstract

Despite of the advances made in the treatment and management, tuberculosis (TB) still remains one of main public health problem. The contrary effects of first and second-line anti-tuberculosis drugs have generated extended research interest in natural products in the hope of devising new antitubercular leads. Interestingly, plethoras of natural products have been discovered to exhibit activity towards various resistant strains of M. tuberculosis. Extensive applications of alkaloids in the field of therapeutics is well-established and nowday's researches being pursued to develop new potent drugs from natural sources for tuberculosis. Alkaloids are categorized in quite a few groups according to their structures and isolation from both terrestrial and marine sources. These new drugs might be a watershed in the battle against tuberculosis. This review summarizes alkaloids, which were found active against Mycobacteria since last ten years with special attention on the study of structure-activity relationship (SAR) and mode of action with their impact in drug discovery and development against tuberculosis.

KEYWORDS:

Alkaloids; Antimycobacterial agents; Drug development; Multi drug resistant tuberculosis; Mycobacterium tuberculosis; Natural products; Tuberculosis

PMID:
28628823
DOI:
10.1016/j.ejmech.2017.06.005
[Indexed for MEDLINE]

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