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Stroke. 2017 Jul;48(7):1890-1894. doi: 10.1161/STROKEAHA.117.016680. Epub 2017 Jun 16.

Dose-Dependent Effect of Statin Pretreatment on Preventing the Periprocedural Complications of Carotid Artery Stenting.

Author information

1
From the Department of Neurology (J.-H.H., S.-I.S., J.K., J.Y.); Department of Radiology (H.W.C.), Keimyung University School of Medicine, Dongsan Medical Center, Daegu, Korea; Department of Neurology (I.C., H.-J.B., M.-K.H.), Department of Neurosurgery (O.-K.K.), and Department of Radiology (C.J.), Seoul National University Bundang Hospital, Seongnam, Korea; and Clinical Trial Center, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea (J.S.L.).
2
From the Department of Neurology (J.-H.H., S.-I.S., J.K., J.Y.); Department of Radiology (H.W.C.), Keimyung University School of Medicine, Dongsan Medical Center, Daegu, Korea; Department of Neurology (I.C., H.-J.B., M.-K.H.), Department of Neurosurgery (O.-K.K.), and Department of Radiology (C.J.), Seoul National University Bundang Hospital, Seongnam, Korea; and Clinical Trial Center, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea (J.S.L.). mkhan@snu.ac.kr.

Abstract

BACKGROUND AND PURPOSE:

We investigated whether statin pretreatment can dose dependently reduce periprocedural complications in patients undergoing carotid artery stenting because of symptomatic carotid artery stenosis.

METHODS:

We enrolled a consecutive series of 397 symptomatic carotid artery stenosis (≥50% stenosis on conventional angiography) treated with carotid artery stenting at 2 tertiary university hospitals over a decade. Definition of periprocedural complications included any stroke, myocardial infarction, and death within 1 month after or during the procedure. Statin pretreatment was divided into 3 categories according to the atorvastatin equivalent dose: none (n=158; 39.8%), standard dose (<40 mg of atorvastatin, n=155; 39.0%), and high dose (≥40 mg; n=84; 21.2%). A multivariable logistic regression analysis with the generalized estimating equation method was used to investigate independent factors in periprocedural complications.

RESULTS:

The patients' mean age was 68.7 years (81.6% men). The periprocedural complication rates across the 3 categories of statin use were 12.0%, 4.5%, and 1.2%. After adjustment, a change in the atorvastatin dose category was associated with reduction in the odds of periprocedural complications for each change in dose category (standard-dose statin: odds ratio, 0.24; 95% confidence interval, 0.07-0.81; high-dose statin: odds ratio, 0.11; 95% confidence interval, 0.01-0.96; P for trend=0.01). Administration of antiplatelet drugs was also an independent factor in periprocedural complications (OR, 0.18; 95% CI, 0.05-0.69).

CONCLUSIONS:

This study shows that statin pretreatment may reduce the incidence of periprocedural complications dose dependently in patients with symptomatic carotid artery stenting.

KEYWORDS:

carotid stenosis; cerebral infarction; cerebrovascular disorders; hydroxymethylglutaryl-CoA reductase inhibitors; stroke

PMID:
28626049
DOI:
10.1161/STROKEAHA.117.016680
[Indexed for MEDLINE]

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