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Microbes Infect. 2017 Sep - Oct;19(9-10):459-463. doi: 10.1016/j.micinf.2017.06.002. Epub 2017 Jun 15.

Doctor says you are cured, but you still feel the pain. Borrelia DNA persistence in Lyme disease.

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Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, 5001 El Paso Dr., El Paso, TX 79905, USA. Electronic address:


Lyme disease is a zoonosis caused by infection with Borrelia burgdorferi (Bb). A great amount of research has attempted to elucidate the mechanisms by which Bb causes inflammation and chronic symptomatology in some patients. Patients often seek unconventional treatments that lack scientific evidence, as medical care is unable to effectively explain and treat their illness. Bb-DNA can persist for long periods of time in some individuals, even after antibiotic therapy. Herein, scientific rationale is presented for a new therapeutic approach against remaining bacterial DNA, and/or increasing the ability of human macrophages to remove extracellular Bb DNA.


Antimicrobial peptides; Borrelia burgdorferi; DNA persistence; Lyme disease; Post-treatment Lyme syndrome; TLR9

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