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J Struct Biol. 2017 Dec;200(3):303-306. doi: 10.1016/j.jsb.2017.06.005. Epub 2017 Jun 16.

Time-resolved cryo-electron microscopy: Recent progress.

Author information

1
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, 650 W. 168th Street, New York, NY 10032, United States; Department of Biological Sciences, Columbia University, United States. Electronic address: jf2192@columbia.edu.

Abstract

Time-resolved cryo-electron microscopy (cryo-EM) combines the known advantages of single-particle cryo-EM in visualizing molecular structure with the ability to dissect the time progress of a reaction between molecules in vitro. Here some of the recent progress of this methodology and its first biological applications are outlined.

KEYWORDS:

Cryo-EM; Microfluidics; RRF; Ribosome recycling; Short-lived states

PMID:
28625887
PMCID:
PMC5732889
DOI:
10.1016/j.jsb.2017.06.005
[Indexed for MEDLINE]
Free PMC Article

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