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Exp Hematol. 2017 Sep;53:26-30. doi: 10.1016/j.exphem.2017.06.002. Epub 2017 Jun 16.

Lifelong dietary intervention does not affect hematopoietic stem cell function.

Author information

1
European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen Antonius Deusinglaan 1, Groningen, The Netherlands.
2
Laboratory of Pediatrics, Section Systems Medicine of Metabolism and Signaling, University Medical Center Groningen, Groningen, The Netherlands; Systems Biology Centre for Energy Metabolism and Ageing, University of Groningen, Groningen, The Netherlands; Groningen Institute for Evolutionary Life Sciences (GELIFES), Department of Behavioral Neuroscience, University of Groningen, Groningen, The Netherlands.
3
Systems Biology Centre for Energy Metabolism and Ageing, University of Groningen, Groningen, The Netherlands; Groningen Institute for Evolutionary Life Sciences (GELIFES), Department of Behavioral Neuroscience, University of Groningen, Groningen, The Netherlands; Centre for Isotope Research, University of Groningen, Groningen, The Netherlands.
4
European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen Antonius Deusinglaan 1, Groningen, The Netherlands; Mouse Clinic for Cancer and Aging, University Medical Center Groningen, University of Groningen Antonius Deusinglaan 1, Groningen, The Netherlands.
5
European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen Antonius Deusinglaan 1, Groningen, The Netherlands; Mouse Clinic for Cancer and Aging, University Medical Center Groningen, University of Groningen Antonius Deusinglaan 1, Groningen, The Netherlands. Electronic address: g.de.haan@umcg.nl.

Abstract

Hematopoietic stem cells (HSCs) undergo a profound functional decline during normal aging. Because caloric or dietary restriction has been shown to delay multiple aspects of the aging process in many species, we explored the consequences of lifelong caloric restriction, or conversely, lifelong excess caloric intake, on HSC numbers and function. Although caloric restriction prevented age-dependent increases in bone marrow cellularity, caloric restriction was not able to prevent functional decline of aged, long-term HSC functioning. A lifelong high-fat diet also did not affect HSC function. We conclude that lifelong caloric interventions fail to prevent or induce loss of age-associated HSC functioning.

PMID:
28625745
DOI:
10.1016/j.exphem.2017.06.002
[Indexed for MEDLINE]

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