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Eur Arch Psychiatry Clin Neurosci. 2018 Feb;268(1):3-15. doi: 10.1007/s00406-017-0820-z. Epub 2017 Jun 17.

The microbiome-gut-brain axis: implications for schizophrenia and antipsychotic induced weight gain.

Author information

1
Pharmacogenetics Research Clinic Centre for Addiction and Mental Health, 250 College Street, R 132, Toronto, ON, Canada.
2
Toronto Western Hospital, Toronto, ON, Canada.
3
St. Michael's Hospital, Toronto, ON, Canada.
4
Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
5
Psychiatric Neurogenetics Lab, Molecular Brain Science Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.
6
Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
7
Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
8
Complex Mental Illness, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.
9
Pharmacogenetics Research Clinic Centre for Addiction and Mental Health, 250 College Street, R 132, Toronto, ON, Canada. daniel.mueller@camh.ca.
10
Department of Psychiatry, University of Toronto, Toronto, ON, Canada. daniel.mueller@camh.ca.

Abstract

With the emergence of knowledge implicating the human gut microbiome in the development and regulation of several physiological systems, evidence has accumulated to suggest a role for the gut microbiome in psychiatric conditions and drug response. A complex relationship between the enteric nervous system, the gut microbiota and the central nervous system has been described which allows for the microbiota to influence and respond to a variety of behaviors and psychiatric conditions. Additionally, the use of pharmaceuticals may interact with and alter the microbiota to potentially contribute to adverse effects of the drug. The gut microbiota has been described in several psychiatric disorders including depression and anxiety, but only a few reports have discussed the role of the microbiome in schizophrenia. The following review examines the evidence surrounding the gut microbiota in behavior and psychiatric illness, the role of the microbiota in schizophrenia and the potential for antipsychotics to alter the gut microbiota and promote adverse metabolic events.

KEYWORDS:

Antipsychotic-induced weight gain; Gut brain axis; Gut microbiome; Schizophrenia

PMID:
28624847
DOI:
10.1007/s00406-017-0820-z
[Indexed for MEDLINE]

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