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Cell Mol Neurobiol. 2018 Apr;38(3):579-593. doi: 10.1007/s10571-017-0510-4. Epub 2017 Jun 16.

BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity.

Author information

1
Department of Anatomy and Neurobiology, Medical University of Gdansk, 1 Debinki Street, 80-211, Gdańsk, Poland. kowiansk@gumed.edu.pl.
2
Department of Health Sciences, Pomeranian University of Slupsk, 64 Bohaterów Westerplatte Str., 76-200, Słupsk, Poland. kowiansk@gumed.edu.pl.
3
Department of Anatomy and Neurobiology, Medical University of Gdansk, 1 Debinki Street, 80-211, Gdańsk, Poland.
4
Department of Health Sciences, Pomeranian University of Slupsk, 64 Bohaterów Westerplatte Str., 76-200, Słupsk, Poland.

Abstract

Brain-derived neurotrophic factor (BDNF) is one of the most widely distributed and extensively studied neurotrophins in the mammalian brain. Among its prominent functions, one can mention control of neuronal and glial development, neuroprotection, and modulation of both short- and long-lasting synaptic interactions, which are critical for cognition and memory. A wide spectrum of processes are controlled by BDNF, and the sometimes contradictory effects of its action can be explained based on its specific pattern of synthesis, comprising several intermediate biologically active isoforms that bind to different types of receptor, triggering several signaling pathways. The functions of BDNF must be discussed in close relation to the stage of brain development, the different cellular components of nervous tissue, as well as the molecular mechanisms of signal transduction activated under physiological and pathological conditions. In this review, we briefly summarize the current state of knowledge regarding the impact of BDNF on regulation of neurophysiological processes. The importance of BDNF for future studies aimed at disclosing mechanisms of activation of signaling pathways, neuro- and gliogenesis, as well as synaptic plasticity is highlighted.

KEYWORDS:

BDNF; Cognition; Development; Neurotrophin; Synaptic plasticity

PMID:
28623429
PMCID:
PMC5835061
DOI:
10.1007/s10571-017-0510-4
[Indexed for MEDLINE]
Free PMC Article

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