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Vaccine. 2017 Jul 13;35(32):3988-3994. doi: 10.1016/j.vaccine.2017.05.084. Epub 2017 Jun 13.

Immunogenicity of mumps virus vaccine candidates matching circulating genotypes in the United States and China.

Author information

1
Department of Infectious Diseases, University of Georgia College of Veterinary Medicine, Athens, GA, United States.
2
Department of Infectious Diseases, University of Georgia College of Veterinary Medicine, Athens, GA, United States; Department of Biomedical Engineering, Duke University, Durham, NC, United States.
3
Department of Infectious Diseases, University of Georgia College of Veterinary Medicine, Athens, GA, United States; Marjorie B. Kovler Viral Oncology Labs, The University of Chicago, Chicago, IL 60637, United States.
4
Department of Infectious Diseases, University of Georgia College of Veterinary Medicine, Athens, GA, United States. Electronic address: bhe@uga.edu.

Abstract

Mumps virus (MuV) causes acute infection in humans with characteristic swelling of the parotid gland. While vaccination has greatly reduced the incidence of MuV infection, there have been multiple large outbreaks of mumps virus (MuV) in highly vaccinated populations. The most common vaccine strain, Jeryl Lynn, belongs to genotype A, which is no longer a circulating genotype. We have developed two vaccine candidates that match the circulating genotypes in the United States (genotype G) and China (genotype F). We found that there was a significant decrease in the ability of the Jeryl Lynn vaccine to produce neutralizing antibody responses to non-matched viruses, when compared to either of our vaccine candidates. Our data suggests that an updated vaccine may allow for better immunity against the circulating MuV genotypes G and F.

KEYWORDS:

Genotype F; Genotype G; Mumps; Vaccine

PMID:
28623030
PMCID:
PMC5785236
DOI:
10.1016/j.vaccine.2017.05.084
[Indexed for MEDLINE]
Free PMC Article

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