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Biomacromolecules. 2017 Aug 14;18(8):2296-2305. doi: 10.1021/acs.biomac.7b00456. Epub 2017 Jun 30.

Hemocompatibility of Degrading Polymeric Biomaterials: Degradable Polar Hydrophobic Ionic Polyurethane versus Poly(lactic-co-glycolic) Acid.

Author information

1
Department of Chemical Engineering and Applied Chemistry, University of Toronto , Toronto, Ontario M5S 3R5, Canada.
2
Institute of Biomaterials and Biomedical Engineering, Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, University of Toronto , Toronto, Ontario M5G 1M1, Canada.
3
Department of Pathology and Laboratory Medicine and Centre for Blood Research, University of British Columbia , Vancouver, British Columbia V6T 1Z3, Canada.
4
Department of Chemistry, University of British Columbia , Vancouver, British Columbia V6T 1Z1, Canada.
5
Faculty of Dentistry, University of Toronto , Toronto, Ontario M5G 1G6, Canada.

Abstract

The use of degradable polymers in vascular tissue regeneration has sparked the need to characterize polymer biocompatibility during degradation. While tissue compatibility has been frequently addressed, studies on polymer hemocompatibility during degradation are limited. The current study evaluated the differences in hemocompatibility (platelet response, complement activation, and coagulation cascade initiation) between as-made and hydrolyzed poly(lactic-co-glycolic) acid (PLGA) and degradable polar hydrophobic ionic polyurethane (D-PHI). Platelet activation decreased (in whole blood) and platelet adhesion decreased (in blood without leukocytes) for degraded versus as-made PLGA. D-PHI showed minimal hemocompatibility changes over degradation. Leukocytes played a major role in mediating platelet activation for samples and controls, as well as influencing platelet-polymer adhesion on the degraded materials. This study demonstrates the importance of assessing the blood compatibility of biomaterials over the course of degradation since the associated changes in surface chemistry and physical state could significantly change biomaterial hemocompatibility.

PMID:
28621927
DOI:
10.1021/acs.biomac.7b00456
[Indexed for MEDLINE]

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