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J Am Acad Dermatol. 2017 Jul;77(1):109-117. doi: 10.1016/j.jaad.2016.11.028.

Evidence-based recommendations for the management of acne fulminans and its variants.

Author information

1
University of California, San Diego, California; Rady Children's Hospital-San Diego, San Diego, California. Electronic address: tgreywal@gmail.com.
2
Pennsylvania State University, State College, Pennsylvania; Hershey Medical Center, Hershey, Pennsylvania.
3
State University of New York Downstate Medical Center, New York, New York.
4
Therapeutics Clinical Research, San Diego, California.
5
Cornell University, Ithaca, New York.
6
Touro University, Henderson, Nevada.
7
University of California, San Diego, California; Rady Children's Hospital-San Diego, San Diego, California.
8
University of California, San Francisco, California.
9
University of Pennsylvania, Philadelphia, Pennsylvania.
10
Thomas Jefferson University, Philadelphia, Pennsylvania.

Abstract

BACKGROUND:

Acne fulminans (AF) is a severe variant of inflammatory acne. It typically manifests as an explosive worsening and ulceration of skin lesions, and can be associated with systemic symptoms. However, there is a paucity of evidence-based information and no clear guidelines concerning the classification and treatment of AF.

OBJECTIVE:

To better define the spectrum of AF and its variants, devise optimal therapeutic approaches, and identify areas of future research.

METHODS:

A panel of physicians with expertise in severe acne vulgaris was convened after a comprehensive literature review of severe acne variants. Priority topics were reviewed and presented by each panelist at a 5-hour conference. Following review of the audiotape and scribed notes from the conference, surveys were utilized to address points of controversy and to clarify consensus recommendations.

RESULTS:

Appropriate clinical case presentations and consensus survey questions were utilized to create final recommendations based on both the literature and the expert consensus.

LIMITATIONS:

Limited evidenced-based data and prospective studies in the literature concerning the treatment of AF is available.

CONCLUSION:

These guidelines better characterize AF and provide health care practitioners approaches to the classification, treatment, and prevention of AF and its variants.

KEYWORDS:

PAPA; PAPASH; SAPHO; acne fulminans; diagnosis; isotretinoin; pseudotumor cerebri syndrome; treatment

PMID:
28619551
DOI:
10.1016/j.jaad.2016.11.028
[Indexed for MEDLINE]

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