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Vision Res. 2017 Oct;139:123-137. doi: 10.1016/j.visres.2017.05.009. Epub 2017 Jun 27.

The inner blood-retinal barrier: Cellular basis and development.

Author information

1
Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, MI, United States.
2
Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, MI, United States. Electronic address: dantonet@umich.edu.

Abstract

The blood-retinal barrier (BRB) regulates transport across retinal capillaries maintaining proper neural homeostasis and protecting the neural tissue from potential blood borne toxicity. Loss of the BRB contributes to the pathophysiology of a number of blinding retinal diseases including diabetic retinopathy. In this review, we address the basis of the BRB, including the molecular mechanisms that regulate flux across the retinal vascular bed. The routes of transcellular and paracellular flux are described as well as alterations in these pathways in response to permeabilizing agents in diabetes. Finally, we provide information on exciting new studies that help to elucidate the process of BRB development or barriergenesis and how understanding this process may lead to new opportunities for barrier restoration in diabetic retinopathy.

KEYWORDS:

Barriergenesis; Blood-retinal barrier; Paracellular permeability; Tight junctions; Transcytosis

PMID:
28619516
PMCID:
PMC5723228
DOI:
10.1016/j.visres.2017.05.009
[Indexed for MEDLINE]
Free PMC Article

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