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Vet Microbiol. 2017 May;203:88-94. doi: 10.1016/j.vetmic.2017.02.016. Epub 2017 Feb 27.

Vaccine immune pressure influences viral population complexity of avian influenza virus during infection.

Author information

1
Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padova, Italy. Electronic address: amilani@izsvenezie.it.
2
Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padova, Italy.
3
MRC-University of Glasgow Center for Virus Research, Glasgow, United Kingdom.
4
Virology department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
5
IFT Corporation, Cairo, Egypt.
6
Boehringer Ingelheim Veterinary Research Center, Hannover, 30559, Germany.
7
Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padova, Italy; Animal Production and Health Laboratory, Joint FAO/IAEA Division, International Atomic Energy Agency, Seibersdorf, Austria.

Abstract

Vaccines are useful tools to control influenza A virus infection in poultry, but they need to be periodically reformulated to guarantee appropriate protection from infection and to limit viral replication and circulation, which could favour the emergence of new variants. In this study, a deep sequencing approach was used to characterize and follow the evolution of the hemagglutinin of the H5N1 highly pathogenic avian influenza viral population in infected animals vaccinated with two vaccines conferring different protection levels. Results from this preliminary investigation suggested that the evolution of the viral population, as well as the abundance and heterogeneity of minority variants could be influenced by the immune pressure conferred by vaccination.

KEYWORDS:

Deep sequencing; Evolution; H5N1; Influenza A virus; Vaccine

PMID:
28619173
DOI:
10.1016/j.vetmic.2017.02.016
[Indexed for MEDLINE]

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