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Ann N Y Acad Sci. 2017 Jun;1398(1):62-71. doi: 10.1111/nyas.13373. Epub 2017 Jun 15.

The healthy effects of strawberry bioactive compounds on molecular pathways related to chronic diseases.

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Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, Ancona, Italy.
Area de Nutricion y Salud, Universidad Internacional Iberoamericana (UNINI), Campeche, Mexico.
Departamento de Quimica Analıtica y Alimentaria, Grupo de Nutricion y Bromatologıa, Universidade de Vigo, Ourense, Spain.
Department of Physiology, Institute of Nutrition and Food Technology "Jose Mataix," Biomedical Research Centre, University of Granada, Granada, Spain.
Dipartimento di Scienze Agrarie, Alimentari e Ambientali, Università Politecnica delle Marche, Ancona, Italy.
Centre for Nutrition & Health, Universidad Europea del Atlantico (UEA), Santander, Spain.


It is generally accepted that a fruit and vegetable-enriched diet is favorable for human health. The consumption of strawberries, in particular, has been related to the maintenance of well-being and the prevention of several chronic diseases, owing to the high contents of antioxidants and phytochemicals present in the fruit. Several biological effects have been explained through the total antioxidant capacity exerted by these bioactive compounds, but recently more intricate mechanisms have begun to be examined. In this context, it has been reported that strawberry phenolics are able to exert anti-inflammatory, anticarcinogenic, antiproliferative, and antiatherosclerotic activities, acting on specific molecular pathways related to antioxidant defenses, metabolism, survival, and proliferation. The overall aim of this work is to discuss and update the cellular and molecular mechanisms recently proposed to clarify the effects of strawberry phenolics on human health, with particular attention to the most common chronic diseases, such as metabolic syndrome, cardiovascular disease, and cancer.


cancer; cardiovascular diseases; inflammation; metabolism; strawberry phenolic compounds

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