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Mol Cell Oncol. 2017 Mar 10;4(3):e1302905. doi: 10.1080/23723556.2017.1302905. eCollection 2017.

Common genetic variation in the germline influences where and how tumors develop.

Carter H1,2,3,4, Ideker T1,2,3,4,5.

Author information

1
Department of Medicine, Division of Medical Genetics, University of California San Diego, La Jolla, CA, USA.
2
Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
3
Cancer Cell Map Initiative (CCMI), La Jolla and San Francisco, CA, USA.
4
Bioinformatics Program, University of California San Diego, La Jolla, CA, USA.
5
Department of Computer Science, University of California San Diego, La Jolla, CA, USA.

Abstract

Germline variation contributes to individual risk for developing specific types of cancer. Analyzing thousands of tumors, we found evidence that the germline also influences vulnerable tissue sites and the mutations that arise in tumor genomes. These associations provide new clues to unravel the biologic mechanisms underlying cancer predisposition.

KEYWORDS:

Cancer predisposition; germline-somatic interactions; tumor evolution

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