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Clin Ophthalmol. 2017 May 30;11:1031-1038. doi: 10.2147/OPTH.S133060. eCollection 2017.

Changes in meibomian gland morphology and ocular higher-order aberrations in eyes with chalazion.

Author information

Department of Ophthalmology, Omiya Hamada Eye Clinic.
Lid and Meibomian Gland Working Group (LIME), Saitama-shi, Saitama.
Department of Ophthalmology, University of Tokyo School of Medicine, Bunkyo-ku, Tokyo.
Department of Ophthalmology, Itoh Clinic, Saitama-shi, Saitama.
Department of Ophthalmology, Oshima Eye Hospital, Fukuoka-shi, Fukuoka, Japan.



To examine the changes in meibomian gland morphology and ocular higher-order aberrations (HOAs) in eyes with chalazion and its excision.


Seven male patients with previous history of chalazion excision and seven control male subjects were enrolled. Changes in meibomian gland morphology (meiboscores, gland dropout, and shortening) were evaluated by using meibography equipped in a wavefront analyzer KR-1W and in a slit-lamp device BG-4M. Ocular HOAs were measured sequentially with KR-1W. The tear film breakup time (BUT) was measured.


Both KR-1W and BG-4M visualized meibomian gland as clear similar images. The tear film BUT (mean ± SD, 5.6±3.0 vs 9.4±2.3 seconds, P=0.025), the total meiboscore (median [interquartile range], 2 (2-3) vs 0 (0-1), P=0.007) as well as the meibomian gland dropout rate (86% vs 14%, P=0.008) and shortening rate (100% vs 29%, P=0.031) differed significantly between the patient and control groups. The first total ocular HOAs (0.142±0.063 vs 0.130±0.015, P=0.80) were similar in both groups, whereas the stability index of the total HOAs over time (0.0041±0.0048 vs -0.0012±0.0020, P=0.030) differed significantly between the patient and control groups.


Chalazion and its excision were associated with dropout and shortening rate of meibomian glands. The morphological changes of meibomian glands in chalazion may be associated to instability of the tear film, which was suggested by the tear film BUT and the stability of ocular HOAs.


chalazion excision; higher-order aberrations; meibography; meibomian gland; wavefront analyzer

Conflict of interest statement

Disclosure Dr Arita holds a patent on the noncontact meibography system used in the study (JP Patent Registration No 5281846, US Patent Publication No 2011-0273550A1, EP Patent Publication No 2189108A1). Drs Fukuoka, Shirakawa, and Morishige report no conflicts of interest in this work.

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