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J Biol Chem. 2017 Jul 28;292(30):12375-12382. doi: 10.1074/jbc.R116.760884. Epub 2017 Jun 14.

Long non-coding RNAs (lncRNAs) and their transcriptional control of inflammatory responses.

Author information

1
From the Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska 68178.
2
From the Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska 68178 xianmingchen@creighton.edu.

Abstract

Long non-coding RNAs (lncRNAs) have emerged as potential key regulators of the inflammatory response, particularly by modulating the transcriptional control of inflammatory genes. lncRNAs may act as an enhancer or suppressor to inflammatory transcription, function as scaffold molecules through interactions with RNA-binding proteins in chromatin remodeling complexes, and modulate dynamic and epigenetic control of inflammatory transcription in a gene-specific and time-dependent fashion. Here, we will review recent literature regarding the role of lncRNAs in transcriptional control of inflammatory responses. Better understanding of lncRNA regulation of inflammation will provide novel targets for the development of new therapeutic strategies.

KEYWORDS:

NF-κB; chromatin remodeling; epigenetics; inflammation; long noncoding RNA (long ncRNA, lncRNA); toll-like receptor (TLR); transcription regulation

PMID:
28615453
PMCID:
PMC5535013
DOI:
10.1074/jbc.R116.760884
[Indexed for MEDLINE]
Free PMC Article

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