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Neurology. 2017 Jul 11;89(2):129-137. doi: 10.1212/WNL.0000000000004081. Epub 2017 Jun 14.

Outcomes of Colorado children with acute flaccid myelitis at 1 year.

Author information

1
From the Departments of Pediatrics (J.A. Martin, M.L.Y., T.L.S.), Infectious Diseases (K.M., S.R.D.), Hospital Medicine (K.M.), Radiology (J.A. Maloney), Child Psychiatry (J.L.), and Physical Medicine and Rehabilitation (T.C., P.K., J.O.), Section of Child Neurology, Children's Hospital Colorado/University of Colorado School of Medicine, Aurora; and Departments of Neurology, Medicine, and Immunology-Microbiology and Neurology Service at the Denver Veterans Affairs Medical Center (S.H.S., K.L.T.), University of Colorado School of Medicine.
2
From the Departments of Pediatrics (J.A. Martin, M.L.Y., T.L.S.), Infectious Diseases (K.M., S.R.D.), Hospital Medicine (K.M.), Radiology (J.A. Maloney), Child Psychiatry (J.L.), and Physical Medicine and Rehabilitation (T.C., P.K., J.O.), Section of Child Neurology, Children's Hospital Colorado/University of Colorado School of Medicine, Aurora; and Departments of Neurology, Medicine, and Immunology-Microbiology and Neurology Service at the Denver Veterans Affairs Medical Center (S.H.S., K.L.T.), University of Colorado School of Medicine. Teri.Schreiner@ucdenver.edu.

Abstract

OBJECTIVE:

We describe long-term functional, neurodiagnostic, and psychosocial outcomes of a cohort of 12 children from Colorado diagnosed with acute flaccid myelitis (AFM) in 2014.

METHODS:

Children were assessed every 3 months for 1 year or until clinical resolution. Assessments included neurologic examination, MRI, EMG/nerve conduction studies (NCS), functional measures (Assisting Hand Assessment, Hammersmith Functional Motor Scale), and Patient-Reported Outcomes Measurement Information System questionnaires.

RESULTS:

Eight of 12 children completed the study. Six of 8 had persistent motor deficits at 1 year; 2 demonstrated full recovery. Four were not enrolled, 2 of whom reported full recovery. The 6 affected were weakest in proximal muscles, showing minimal to no improvement and significant atrophy at 1 year. All patients improved in distal muscle groups. Cranial nerve dysfunction resolved in 2 of 5 and improved in all. Four of 5 showed progressive functional improvement at 6 and 12 months. Two of 8 reported pain at 1 year. Three of 8 reported depressive symptoms. Repeat MRI was performed in 7 of 8 children a median of 7 months after onset and showed significant improvement or normalization in all but one child. Repeat EMG/NCS was performed on 4 children a median of 8 months after onset and showed ongoing denervation and chronic reinnervation in 3 children with persistent deficits.

CONCLUSIONS:

At 1 year, children with AFM demonstrated functional gains but weakness persisted. EMG changes correlated with persistent deficits better than imaging. Despite improvements, AFM had substantial long-term functional effects on affected children.

PMID:
28615421
PMCID:
PMC5501931
DOI:
10.1212/WNL.0000000000004081
[Indexed for MEDLINE]
Free PMC Article

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