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ACS Appl Mater Interfaces. 2017 Jun 28;9(25):21116-21123. doi: 10.1021/acsami.7b03816. Epub 2017 Jun 14.

Molybdenum Disulfide Nanoparticles as Multifunctional Inhibitors against Alzheimer's Disease.

Han Q1,2, Cai S1, Yang L1, Wang X1, Qi C1, Yang R1,2, Wang C1,2.

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CAS Center of Excellence for Nanoscience, National Center for Nanoscience and Technology, UCAS , Beijing 100190, P. R. China.
Sino-Danish College, Sino-Danish Center for Education and Research, UCAS , Beijing 100190, P. R. China.


The complex pathogenic mechanisms of Alzheimer's disease (AD) include the aggregation of β-amyloid peptides (Aβ) into oligomers or fibrils as well as Aβ-mediated oxidative stress, which require comprehensive treatment. Therefore, the inhibition of Aβ aggregation and free-radical scavenging are essential for the treatment of AD. Nanoparticles (NPs) have been found to influence Aβ aggregation process in vitro. Herein, we report the inhibition effects of molybdenum disulfide (MoS2) NPs on Aβ aggregation. Polyvinylpyrrolidone-functionalized MoS2 NPs were fabricated by a pulsed laser ablation method. We find that MoS2 NPs exhibit multifunctional effects on Aβ peptides: inhibiting Aβ aggregation, destabilizing Aβ fibrils, alleviating Aβ-induced oxidative stress, as well as Aβ-mediated cell toxicity. Moreover, we show that MoS2 NPs can block the formation of the Ca2+ channel induced by Aβ fibrils in the cell membrane for the first time. Thus, these observations suggest that MoS2 NPs have great potential for a multifunctional therapeutic agent against amyloid-related diseases.


MoS2 nanoparticles; amyloid peptide; antioxidant activity; neuronal cytotoxicity; pulsed laser ablation

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