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Aliment Pharmacol Ther. 2017 Aug;46(3):213-224. doi: 10.1111/apt.14173. Epub 2017 Jun 14.

Systematic review with meta-analysis: faecal microbiota transplantation for the induction of remission for active ulcerative colitis.

Author information

1
Department of Gastroenterology, The Queen Elizabeth Hospital, Woodville, SA, Australia.
2
School of Medicine, University of Adelaide, Adelaide, SA, Australia.
3
Departments of Medicine, Epidemiology and Biostatistics, Western University, London, ON, Canada.
4
St Mark's Hospital, Harrow, UK.
5
Department of Surgery and Cancer, Imperial College, London, UK.
6
IBD Service Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Adelaide, SA, Australia.

Abstract

BACKGROUND:

Faecal microbiota transplantation (FMT) is emerging as a novel therapy for ulcerative colitis (UC). Interpretation of efficacy of FMT for UC is complicated by differences among studies in blinding, FMT administration procedures, intensity of therapy and donor stool processing methods.

AIM:

To determine whether FMT is effective and safe for the induction of remission in active UC.

METHODS:

Medline (Ovid), Embase and the Cochrane Library were searched from inception through February 2017. Original studies reporting remission rates following FMT for active UC were included. All study designs were included in the systematic review and a meta-analysis performed including only randomised controlled trials (RCTs).

RESULTS:

There were 14 cohort studies and four RCTs that used markedly different protocols. In the meta-analysis of RCTs, clinical remission was achieved in 39 of 140 (28%) patients in the donor FMT groups compared with 13 of 137 (9%) patients in the placebo groups; odds ratio 3.67 (95% CI: 1.82-7.39, P<.01). Clinical response was achieved in 69 of 140 (49%) donor FMT patients compared to 38 of 137 (28%) placebo patients; odds ratio 2.48 (95% CI: 1.18-5.21, P=.02). In cohort studies, 39 of 168 (24%; 95% CI: 11%-40%) achieved clinical remission.

CONCLUSIONS:

Despite variation in processes, FMT appears to be effective for induction of remission in UC, with no major short-term safety signals. Further studies are needed to better define dose frequency and preparation methods, and to explore its feasibility, efficacy and safety as a maintenance agent.

PMID:
28612983
DOI:
10.1111/apt.14173
[Indexed for MEDLINE]
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