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Med Sci (Paris). 2017 May;33(5):499-505. doi: 10.1051/medsci/20173305013. Epub 2017 Jun 14.

[The biological complexity of Polycomb group proteins: the case of EZH2].

[Article in French]

Author information

1
Centre de recherche en cancérologie de Marseille, U1068 Inserm, UMR 7258 CNRS, Aix-Marseille Université, 27, boulevard Lei Roure, CS30059, 13273 Marseille Cedex 09, France.
2
Centre de recherche en cancérologie de Marseille, U1068 Inserm, UMR 7258 CNRS, Aix-Marseille Université, 27, boulevard Lei Roure, CS30059, 13273 Marseille Cedex 09, France - CBT-1409 Inserm, Aix-Marseille Université, Institut Paoli-Calmettes, Marseille, France.

Abstract

Polycomb Group proteins (PcG) are repressive epigenetic factors essential for development and involved in numerous cancer processes, yet their modes of action and recruitment to specific genomic loci are not fully understood. Recently, it has been shown that the PcG protein recruitment is a dynamic process, contrary to what was foreseen in the initial hierarchical model. In addition, EZH2, a key PcG protein, can be associated to transcribed genes, challenging the former function of PcG proteins as transcriptional repressors. Furthermore, the dual role of EZH2, which can act as an oncogene or a tumor suppressor depending on the cellular type, illustrates the functional complexity of PcG proteins.

PMID:
28612725
DOI:
10.1051/medsci/20173305013
[Indexed for MEDLINE]
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