Format

Send to

Choose Destination
J Vet Intern Med. 2017 Jul;31(4):1028-1034. doi: 10.1111/jvim.14737. Epub 2017 Jun 13.

Breed, Coat Color, and Hair Length as Risk Factors for Hyperthyroidism in Cats.

Author information

1
Department of Clinical Science and Services, Royal Veterinary College, University of London, London, UK.
2
Research Support Office, Royal Veterinary College, University of London, London, UK.
3
Department of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, UK.

Abstract

BACKGROUND:

Hyperthyroidism is very common in older cats, but the etiopathogenesis is poorly understood. Decreased risk of hyperthyroidism has been reported in certain colorpoint breeds, and this observation previously has been hypothesized to result from relatively greater tyrosine availability for thyroid hormone production because of limited ability to convert tyrosine to melanin pigment. However, studies investigating a potential link between coat pigmentation and risk of hyperthyroidism are limited.

OBJECTIVE:

To identify associations between coat phenotype and hyperthyroidism by investigation of breed, coat color, and hair length as risk factors for the disease.

ANIMALS:

Data were used from 4,705 cats aged ≥10 years, referred to a single veterinary teaching hospital (2006-2014) in the United Kingdom.

METHODS:

Retrospective, epidemiological, cross-sectional study using Bayesian multivariable logistic regression to assess risk factors for hyperthyroidism.

RESULTS:

Burmese (odds ratio [OR], 0.01; 0.00-0.23; P = .004), Tonkinese (OR, 0.05; 0.00-0.95; P = .046), Persian (OR, 0.21; 0.10-0.44; P < .001), Siamese (OR, 0.27; 0.12-0.61; P = .002), Abyssinian (OR, 0.04; 0.00-0.74; P = .031), and British shorthair (OR, 0.47; 0.28-0.79; P = .004) breeds had decreased risk of hyperthyroidism compared to domestic shorthairs. Longhaired, nonpurebred cats (OR, 1.30; 1.03-1.64; P = .028) were at increased risk of hyperthyroidism. Coat color/pattern was not associated with hyperthyroidism in nonpurebred cats.

CONCLUSIONS AND CLINICAL IMPORTANCE:

We identified decreased risk of hyperthyroidism in the Tonkinese, Abyssinian, and British shorthair breeds, identified an association between risk of hyperthyroidism and hair length, and confirmed decreased risk in Burmese, Siamese, and Persian breeds. Additional studies are warranted to further investigate these findings.

KEYWORDS:

Cat; Pigment; Tyrosinase; Tyrosine

PMID:
28612380
PMCID:
PMC5508346
DOI:
10.1111/jvim.14737
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center