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Biomed Pharmacother. 2017 Aug;92:998-1009. doi: 10.1016/j.biopha.2017.06.003. Epub 2017 Jun 9.

An overview on immunoregulatory and anti-inflammatory properties of chrysin and flavonoids substances.

Author information

1
Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences (MUMS), Mashhad, Islamic Republic of Iran; Social Security Organization (SSO), Mashhad, Islamic Republic of Iran.
2
Inflammation and Inflammatory Diseases Research Center, Mashhad University of Medical Science (MUMS), Mashhad, Islamic Republic of Iran.
3
Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences (MUMS), Mashhad, Islamic Republic of Iran. Electronic address: hosseinzadehh@mums.ac.ir.

Abstract

Inflammation and the pro-inflammatory cytokines are associated with numerous chronic diseases. Studies suggest that flavonoids, plant polyphenolic compound derivatives from natural origin, have a wide range of putative biological activities. Similar to other flavonoids, chrysin (CH) by its anti-oxidative and anti-inflammatory effects is a potential prophylactic agent in immunopathological and physicochemical injuries. This is an overview on putative immunomodulatory activities of flavonoids and beneficial health effects of these substances particularly, CH in the immune system. CH possesses potent immune-protective effects and suppresses inflammation in innate immune system which results to avoid damages induced by neutrophils and macrophages and suppresses immuno-inflammatory responses. Furthermore, beneficial effects of chrysin on inhibition of serum levels nuclear transcription factor κB (NF-κB) p65 unit, tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), IL-6, IL-12, IL-17A, interferon gamma (IFN-γ) was reported. Moreover, CH has been known as the antagonist of NF-kB and the agonist of peroxisome proliferator-activated receptor gamma (PPAR-γ) which in down regulation of the key pro-inflammatory enzymes such as myeloperoxidase (MPO), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), phospholipase A2, and prostanoids. Therefore, CH can improve immune system and neurodegenerative diseases. In recent years, there has been an increasing interest in compound derivatives from natural origin. Taken together, evidences show that flavonoids may have health-promoting and disease-preventing dietary compounds with important benefits in modern life styles.

KEYWORDS:

Anti-inflammatory; Chrysin; Cytokines; Flavonoids; Immunomodulatory; Polyphenols

PMID:
28609844
DOI:
10.1016/j.biopha.2017.06.003
[Indexed for MEDLINE]

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