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Hippocampus. 2017 Oct;27(10):1040-1053. doi: 10.1002/hipo.22751. Epub 2017 Jun 30.

Theta band power increases in the posterior hippocampus predict successful episodic memory encoding in humans.

Author information

1
Department of Neurological Surgery, University of Texas, Southwestern Medical Center, Dallas, Texas, 75390.
2
Center for Vital Longevity, University of Texas at Dallas, Dallas, Texas, 75390.
3
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104.
4
Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104.

Abstract

Functional differences in the anterior and posterior hippocampus during episodic memory processing have not been examined in human electrophysiological data. This is in spite of strong evidence for such differences in rodent data, including greater place cell specificity in the dorsal hippocampus, greater sensitivity to the aversive or motivational content of memories in ventral regions, connectivity analyses identifying preferential ventral hippocampal connections with the amygdala, and gene expression analyses identifying a dorsal-ventral gradient. We asked if memory-related oscillatory patterns observed in human hippocampal recordings, including the gamma band and slow-theta (2.5-5 Hz) subsequent memory effects, would exhibit differences along the longitudinal axis and between hemispheres. We took advantage of a new dataset of stereo electroencephalography patients with simultaneous, robotically targeted anterior, and posterior hippocampal electrodes to directly compare oscillatory subsequent memory effects during item encoding. This same data set allowed us to examine left-right connectivity and hemispheric differences in hippocampal oscillatory patterns. Our data suggest that a power increase during successful item encoding in the 2.5-5 Hz slow-theta frequency range preferentially occurs in the posterior hippocampus during the first 1,000 ms after item presentation, while a gamma band power increase is stronger in the dominant hemisphere. This dominant-nondominant pattern in the gamma range appears to reverse during item retrieval, however. Intrahippocampal phase coherence was found to be stronger during successful item encoding. Our phase coherence data are also consistent with existing reports of a traveling wave for theta oscillations propagating along the septotemporal (longitudinal) axis of the human hippocampus. We examine how our findings fit with theories of functional specialization along the hippocampal axis.

KEYWORDS:

anterior hippocampus; episodic memory; posterior hippocampus; subsequent memory effect; theta

PMID:
28608960
PMCID:
PMC6517838
DOI:
10.1002/hipo.22751
[Indexed for MEDLINE]
Free PMC Article

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