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Mult Scler J Exp Transl Clin. 2016 Jun 3;2:2055217316652907. doi: 10.1177/2055217316652907. eCollection 2016 Jan-Dec.

A case of presumed herpes keratouveitis in a patient treated with fingolimod.

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Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute, Cleveland Clinic Foundation, USA.


We discuss a case of presumed bilateral herpes simplex keratouveitis in a 36-year-old multiple sclerosis patient switched to fingolimod from glatiramer acetate. Fingolimod treatment appears to increase the risk of herpesvirus infections, including with herpes simplex virus and varicella zoster virus. This case report reviews the potential immunology behind this risk, and identifies the need for further research, including ways to minimize and stratify risk for herpesvirus reactivation.


Multiple sclerosis; adverse events; disease-modifying therapies; fingolimod

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