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Chem Biol Interact. 2017 Aug 1;273:154-159. doi: 10.1016/j.cbi.2017.06.006. Epub 2017 Jun 9.

Protective effect of rutin on humoral and cell mediated immunity in rat model.

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Faculty of Pharmacy, Gujarat Technological University, Ahmedabad, Gujarat, India; Shri Ram Institute of Technology- Pharmacy, Jabalpur, Madhya Pradesh, India. Electronic address:
A.R. College of Pharmacy, Vallabh Vidyanagar, Gujarat, India. Electronic address:


Diet and dietary intake can persuade the development, safeguard and proper functioning of immune system. Ruin, an important bioflavonoid, is abundantly found in various foodstuffs. Rutin has been acknowledged for its protective and beneficial effects on various aspects of the biological system. The present study was aimed to examine the effect of rutin on the regulation of the immune response in experimental animal models. Effect of rutin of cellular immunity was determined by delayed-type hypersensitivity (DTH) response, carbon clearance assay, leucocyte mobilization test, and cyclophosphamide-induced myelosuppression, whereas humoral immunity was analyzed by the haemagglutinating antibody (HA) titre assay. Rutin (25, 50 and 100 mg/kg, p.o.) evoked a significant increase in antibody titre in the haemagglutination test, increased immunoglobulin levels, and enhanced the delayed type hypersensitivity reaction induced by sheep red blood cells. It also significantly restored the functioning of leucocytes in cyclophosphamide treated rats and augmented phagocytic index in the carbon clearance assay. The outcomes from the present study indicate that rutin possesses sufficient potential for increasing immune activity by cellular and humoral mediated mechanisms.


Antibody; Immunity; Immunoglobulin; Myelosuppression; Rutin

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