Quick change: post-transcriptional regulation in Pseudomonas

FEMS Microbiol Lett. 2017 Aug 1;364(14):fnx125. doi: 10.1093/femsle/fnx125.

Abstract

Pseudomonas species have evolved dynamic and intricate regulatory networks to fine-tune gene expression, with complex regulation occurring at every stage in the processing of genetic information. This approach enables Pseudomonas to generate precise individual responses to the environment in order to improve their fitness and resource economy. The weak correlations we observe between RNA and protein abundance highlight the significant regulatory contribution of a series of intersecting post-transcriptional pathways, influencing mRNA stability, translational activity and ribosome function, to Pseudomonas environmental responses. This review examines our current understanding of three major post-transcriptional regulatory systems in Pseudomonas spp.; Gac/Rsm, Hfq and RimK, and presents an overview of new research frontiers, emerging genome-wide methodologies, and their potential for the study of global regulatory responses in Pseudomonas.

Keywords: Pseudomonas; post-transcriptional regulation; regulatory responses; ribosomal modification; signalling pathway; translational control.

Publication types

  • Review

MeSH terms

  • Bacterial Proteins / genetics
  • Gene Expression Regulation, Bacterial*
  • Gene Regulatory Networks
  • Genomics
  • Host Factor 1 Protein / genetics
  • Pseudomonas / genetics*
  • RNA Processing, Post-Transcriptional / genetics*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Ribosomes / genetics
  • Ribosomes / metabolism
  • Signal Transduction

Substances

  • Bacterial Proteins
  • Host Factor 1 Protein
  • RNA, Messenger