Format

Send to

Choose Destination
Clin Infect Dis. 2017 Aug 15;65(4):661-668. doi: 10.1093/cid/cix344.

Public Health Impact of Congenital Toxoplasmosis and Cytomegalovirus Infection in Belgium, 2013: A Systematic Review and Data Synthesis.

Author information

1
Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke.
2
Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp.
3
Institute of Health and Society, Université catholique de Louvain, Brussels.
4
Department of Clinical Biology, Microbiology and Immunology, Ghent University Hospital.
5
School of Life Sciences, Hasselt University, Diepenbeek.
6
Laboratory of Clinical Microbiology, AZ Sint-Lucas, Ghent.
7
Interuniversity Institute for Biostatistics and statistical Bioinformatics, Hasselt University, Diepenbeek.
8
Centre for Health Economics Research & Modelling Infectious Diseases, Vaccine & Infectious Disease Institute.
9
Epidemiology and Social Medicine, University of Antwerp.
10
Department of Public Health and Surveillance, Scientific Institute of Public Health, Brussels, Belgium.

Abstract

Congenital toxoplasmosis (CT) and cytomegalovirus infection (cCMV) may cause significant morbidity and even fetal or neonatal mortality. We aimed to quantify the disease burden of CT and cCMV in Belgium in terms of disability-adjusted life years (DALYs) and identify data gaps. The public health impact of CT and cCMV in Belgium in 2013 was 188 (95% uncertainty interval [UI], 43-419) and 1976 (95% UI, 757-4067) DALYs, respectively. The major data gaps identified were representative Belgian studies; information on important sequelae, intrauterine mortality, and termination of pregnancy; and late onset sequelae. A scenario analysis showed important increases in years of life lost when the burden due to fetal losses was included and decreases in DALYs when comprehensive CT prevention measures were conducted. Addressing the key data gaps identified may allow generation of the data needed to break the vicious circle of underrecognition.

KEYWORDS:

DALY; burden of disease; congenital infections; data gaps

PMID:
28605518
DOI:
10.1093/cid/cix344
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center