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Oncogene. 2017 Oct 12;36(41):5661-5667. doi: 10.1038/onc.2017.184. Epub 2017 Jun 12.

LncRNA-mediated regulation of cell signaling in cancer.

Peng WX1,2, Koirala P2,3, Mo YY2,4.

Author information

1
Department of Cell Biology, School of Medicine, Jiangsu University, Zhenjiang, China.
2
Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA.
3
Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS, USA.
4
Department of Pharmacology/Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.

Abstract

To date, a large number of long non-coding RNAs (lncRNAs) have been recently discovered through functional genomics studies. Importantly, lncRNAs have been shown, in many cases, to function as master regulators for gene expression and thus, they can play a critical role in various biological functions and disease processes including cancer. Although the lncRNA-mediated gene expression involves various mechanisms, such as regulation of transcription, translation, protein modification, and the formation of RNA-protein or protein-protein complexes, in this review, we discuss the latest developments primarily in important cell signaling pathways regulated by lncRNAs in cancer.

PMID:
28604750
PMCID:
PMC6450570
DOI:
10.1038/onc.2017.184
[Indexed for MEDLINE]
Free PMC Article

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