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Int J Mol Sci. 2017 Jun 12;18(6). pii: E1242. doi: 10.3390/ijms18061242.

Legume Lectins: Proteins with Diverse Applications.

Author information

1
CONACyT-Universidad de Sonora, Blvd. Luis Encinas y Rosales, Hermosillo, Sonora 83000, Mexico. Irlanda.lagarda@unison.mx.
2
Coordinacion de Ciencia de los Alimentos, Centro de Investigacion en Alimentacion y Desarrollo, A.C., Apartado Postal 1735, Hermosillo, Sonora 83304, Mexico. gupa@ciad.mx.
3
Coordinacion de Ciencia de los Alimentos, Centro de Investigacion en Alimentacion y Desarrollo, A.C., Apartado Postal 1735, Hermosillo, Sonora 83304, Mexico. lvazquez@ciad.mx.

Abstract

Lectins are a diverse class of proteins distributed extensively in nature. Among these proteins; legume lectins display a variety of interesting features including antimicrobial; insecticidal and antitumor activities. Because lectins recognize and bind to specific glycoconjugates present on the surface of cells and intracellular structures; they can serve as potential target molecules for developing practical applications in the fields of food; agriculture; health and pharmaceutical research. This review presents the current knowledge of the main structural characteristics of legume lectins and the relationship of structure to the exhibited specificities; provides an overview of their particular antimicrobial; insecticidal and antitumor biological activities and describes possible applications based on the pattern of recognized glyco-targets.

KEYWORDS:

antimicrobial; cancer; insecticidal; lectin; legume

PMID:
28604616
PMCID:
PMC5486065
DOI:
10.3390/ijms18061242
[Indexed for MEDLINE]
Free PMC Article

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