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Curr Med Res Opin. 2017 Oct;33(10):1843-1851. doi: 10.1080/03007995.2017.1341868. Epub 2017 Jul 11.

Correlates of basal insulin persistence among insulin-naïve people with type 2 diabetes: results from a multinational survey.

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a Loyola University Maryland , Baltimore , MD , USA.
b Eli Lilly and Company , Indianapolis , IN , USA.
c Analysis Group Inc. , New York , NY , USA.
d Lilly Deutschland GmbH , Bad Homburg , Germany.



People with T2DM who initiate basal insulin therapy often stop therapy temporarily or permanently soon after initiation. This study analyzes the reasons for and correlates of stopping and restarting basal insulin therapy among people with T2DM.


An online survey was completed by 942 insulin-naïve adults with self-reported T2DM from Brazil, France, Germany, Japan, Spain, UK, and US. Respondents had initiated basal insulin therapy within the 3-24 months before survey participation and met criteria for one of three persistence groups: continuers had no gaps of ≥7 days in basal insulin treatment; interrupters had at least one gap in insulin therapy of ≥7 days within the first 6 months after initiation and had since restarted basal insulin; and discontinuers stopped using basal insulin within the first 6 months after initiation and had not restarted.


Physician recommendations and cost were strongly implicated in patients stopping and not resuming insulin therapy. Continuous persistence was lower for patients with more worries about insulin initiation, greater difficulties and weight gain while using insulin, and higher for those using pens and perceiving their diabetes as severe. Repeated interruption of insulin therapy was associated with hyperglycemia and treatment burden while using insulin. Resumption and perceived likelihood of resumption were associated with hyperglycemia upon insulin cessation. Perceived likelihood of resumption among discontinuers was associated with perceived benefits of insulin.


Better understanding of the risk factors for patient cessation and resumption of basal insulin therapy may help healthcare providers improve persistence with therapy.


Insulin persistence; patient perceptions; physician recommendations; type 2 diabetes

[Indexed for MEDLINE]

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