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Neuroimage Clin. 2017 May 26;15:401-407. doi: 10.1016/j.nicl.2017.05.023. eCollection 2017.

Prematurity and brain perfusion: Arterial spin labeling MRI.

Author information

1
ITAB-Institute of Advanced Biomedical Technologies, University "G. d'Annunzio", Via Luigi Polacchi 11, 66100 Chieti, Italy; Neuroradiology Unit, Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genoa, Italy. Electronic address: domenicotortora@gaslini.org.
2
Ophthalmology Clinic, Department of Medicine and Aging Sciences, University "G. d'Annunzio", Via dei Vestini, 66100 Chieti, Italy. Electronic address: pamattei@unich.it.
3
ITAB-Institute of Advanced Biomedical Technologies, University "G. d'Annunzio", Via Luigi Polacchi 11, 66100 Chieti, Italy; Department of Neuroscience and Imaging, University "G. d'Annunzio", Via dei Vestini, 66100 Chieti, Italy. Electronic address: riccardo.navarra@unich.it.
4
ITAB-Institute of Advanced Biomedical Technologies, University "G. d'Annunzio", Via Luigi Polacchi 11, 66100 Chieti, Italy; Department of Neuroscience and Imaging, University "G. d'Annunzio", Via dei Vestini, 66100 Chieti, Italy. Electronic address: v.panara@rad.unich.it.
5
Department of Paediatrics, Neonatology and Neonatal Intensive Care Unit, University Hospital of Chieti, Via dei Vestini, 66100 Chieti, Italy. Electronic address: ritasalomone@tiscali.it.
6
Neuroradiology Unit, Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genoa, Italy. Electronic address: andrearossi@gaslini.org.
7
Department of Neurology, University of Pennsylvania Perelman School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA. Electronic address: detre@mail.med.upenn.edu.
8
ITAB-Institute of Advanced Biomedical Technologies, University "G. d'Annunzio", Via Luigi Polacchi 11, 66100 Chieti, Italy; Department of Neuroscience and Imaging, University "G. d'Annunzio", Via dei Vestini, 66100 Chieti, Italy. Electronic address: caulo@unich.it.

Abstract

PURPOSE:

Abnormal brain perfusion is a critical mechanism in neonatal brain injury. The aim of the present study was to compare Cerebral Blood Flow (CBF) evaluated with ASL MRI in three groups of neonates: preterms without brain lesions on MRI (PN), preterms with periventricular white matter lesions (PNp) and term neonates with normal MRI (TN). The correlation between CBF and clinical outcome was explored.

MATERIALS AND METHODS:

The institutional review board approved this prospective study and waived informed consent. The perfusion ASL data from 49 consecutive preterm neonates (PN) studied at term-equivalent age and 15 TN were evaluated. Statistically significant differences in gray matter CBF were evaluated by using a linear mixed-model analysis and Mann-Whitney U test. Logistic regression analysis was used to assess the relation between CBF and neuromotor outcome at 12 months.

RESULTS:

Comparison of means indicated that the CBF of the whole brain were significantly higher in PN compared to TN (P = 0.011). This difference remained significant when considering the frontal (P = 0.038), parietal (P = 0.002), temporal (P = 0.030), occipital (P = 0.041) and cerebellar (P = 0.010) gray matter. In the PN group, lower CBF in basal ganglia was associated with a worse neuromotor outcome (P = 0.012).

CONCLUSIONS:

ASL MRI demonstrated differences in brain perfusion of the basal ganglia between PN and TN. In PN, a positive correlation between CBF and neuromotor outcome was demonstrated in this area.

KEYWORDS:

ASL, arterial spin labeling; Brain perfusion; CBF, cerebral blood flow; HIE, hypoxic-ischemic encephalopathy; Neonate; PN, preterm neonate with normal MRI; PNp, preterm neonate periventricular white matter lesions; PVL, periventricular leukoencephalopathy; Prematurity; TN, term neonate with normal MRI

PMID:
28603687
PMCID:
PMC5454138
DOI:
10.1016/j.nicl.2017.05.023
[Indexed for MEDLINE]
Free PMC Article

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