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Cancer Res Treat. 2018 Apr;50(2):582-589. doi: 10.4143/crt.2017.048. Epub 2017 Jun 9.

Effectiveness of Gastric Cancer Screening on Gastric Cancer Incidence and Mortality in a Community-Based Prospective Cohort.

Kim H1,2,3, Hwang Y1,2,3, Sung H1,2,3, Jang J1,2,3, Ahn C1,2,3, Kim SG4, Yoo KY2,5, Park SK1,2,3.

Author information

1
Department of Biomedical Science, Seoul National University College of Medicine, Seoul, Korea.
2
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
3
Cancer Research Center, Seoul National University, Seoul, Korea.
4
Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
5
The Armed Forces Capital Hospital, Seongnam, Korea.

Abstract

PURPOSE:

This study was performed to investigate the effectiveness of gastric cancer (GC) screening methods in a community-based prospective cohort of the Korean Multi-center Cancer Cohort (KMCC) with over a 10-year follow-up.

MATERIALS AND METHODS:

A total 10,909 and 4,773 subjects from the KMCC with information on gastroendoscopy (GE) and upper gastrointestinal series (UGIS) were included in this study. Cox proportional hazard model adjusted for age, sex, Helicobacter pylori infection, cigarette smoking, and alcohol drinking was used to estimate the hazard ratios (HRs) and 95% confidence interval (CI).

RESULTS:

The GE screened subjects had almost half the risk of GC-specific death than that of unscreened subjects (HR, 0.58; 95% CI, 0.36 to 0.94). Among the GC patients, GE screenees had a 2.24-fold higher survival rate than that of the non-screenees (95% CI, 1.61 to 3.11). In particular, GE screenees who underwent two or more screening episodes had a higher survival rate than that of the non-screenees (HR, 13.11; 95% CI, 7.38 to 23.30). The effectiveness of GE screening on reduced GC mortality and increased survival rate of GC patients was better in elderly subjects (≥ 65 years old) (HR, 0.47; 95% CI, 0.24 to 0.95 and HR, 8.84; 95% CI, 3.63 to 21.57, respectively) than that in younger subjects (< 65 years old) (HR, 0.66; 95% CI, 0.34 to 1.29 and HR, 1.83; 95% CI, 1.24 to 2.68, respectively). In contrast, UGIS screening had no significant relation to GC mortality and survival.

CONCLUSION:

The findings of this study suggest that a decreased GC-specific mortality and improved survival rate in GC patients can be achieved through GE screening.

KEYWORDS:

Cohort studies; Gastrointestinal endoscopy; Gastroscopy; Mortality; Stomach neoplasms

PMID:
28602053
PMCID:
PMC5912132
DOI:
10.4143/crt.2017.048
[Indexed for MEDLINE]
Free PMC Article

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